BOVINE ENDOZEPINE POTENTIATES MORPHINE ANALGESIA IN MICE

被引：6

作者：

CHEN, YZ

WANG, JY

ZHOU, S

SHOYAB, M

机构：

[1] BRISTOL MYERS SQUIBB,PHARMACEUT RES INST,3005 1ST AVE,SEATTLE,WA 98121

[2] CHINA JAPAN FRIENDSHIP HOSP,INST CLIN MED SCI,BEIJING,PEOPLES R CHINA

[3] BEIJING UNIV,DEPT BIOL,BEIJING,PEOPLES R CHINA

来源：

LIFE SCIENCES | 1991年 / 48卷 / 17期

关键词：

D O I：

10.1016/0024-3205(91)90129-Y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This paper describes the influence of bovine endozepine (BEP) on the analgesic effect of morphine. The intraventricular administration of BEP between doses of 2-4 nmole in mice resulted in the potentiation of the morphine-analgesic effect. The basic pain threshold did not change when BEP was given alone, thus indicating that BEP is unable to elicit analgesic effects alone. Intravenous injection of BEP in the dose range of 5-7.5 mg/kg also potentiated the analgesic effect of morphine. These observations suggest that endozepine can act as a regulator of pain.

引用

收藏

页码：PL79 / PL83

页数：5

相关论文

共 14 条

[1] IDENTIFICATION OF DES-(GLY-ILE)-ENDOZEPINE AS AN EFFECTOR OF CORTICOTROPIN-DEPENDENT ADRENAL STEROIDOGENESIS - STIMULATION OF CHOLESTEROL DELIVERY IS MEDIATED BY THE PERIPHERAL BENZODIAZEPINE RECEPTOR [J].

BESMAN, MJ ;

YANAGIBASHI, K ;

LEE, TD ;

KAWAMURA, M ;

HALL, PF ;

SHIVELY, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) :4897-4901

[2] ISOLATION AND CHARACTERIZATION OF PORCINE DIAZEPAM-BINDING INHIBITOR, A POLYPEPTIDE NOT ONLY OF CEREBRAL OCCURRENCE BUT ALSO COMMON IN INTESTINAL TISSUES AND WITH EFFECTS ON REGULATION OF INSULIN RELEASE [J].

CHEN, ZW ;

AGERBERTH, B ;

GELL, K ;

ANDERSSON, M ;

MUTT, V ;

OSTENSON, CG ;

EFENDIC, S ;

BARROSSODERLING, J ;

PERSSON, B ;

JORNVALL, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 174 (02) :239-245

[3] STUDY OF AN OCTADECANEUROPEPTIDE DERIVED FROM DIAZEPAM BINDING INHIBITOR (DBI) - BIOLOGICAL-ACTIVITY AND PRESENCE IN RAT-BRAIN [J].

FERRERO, P ;

SANTI, MR ;

CONTITRONCONI, B ;

COSTA, E ;

GUIDOTTI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (03) :827-831

[4] CLONING AND EXPRESSION OF CDNA FOR HUMAN DIAZEPAM BINDING INHIBITOR, A NATURAL LIGAND OF AN ALLOSTERIC REGULATORY SITE OF THE GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTOR [J].

GRAY, PW ;

GLAISTER, D ;

SEEBURG, PH ;

GUIDOTTI, A ;

COSTA, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7547-7551

[5] ISOLATION, CHARACTERIZATION, AND PURIFICATION TO HOMOGENEITY OF AN ENDOGENOUS POLYPEPTIDE WITH AGONISTIC ACTION ON BENZODIAZEPINE RECEPTORS [J].

GUIDOTTI, A ;

FORCHETTI, CM ;

CORDA, MG ;

KONKEL, D ;

BENNETT, CD ;

COSTA, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (11) :3531-3535

[6] ACYL-COA-BINDING PROTEIN IN THE RAT - PURIFICATION, BINDING CHARACTERISTICS, TISSUE CONCENTRATIONS AND AMINO-ACID SEQUENCE [J].

KNUDSEN, J ;

HOJRUP, P ;

HANSEN, HO ;

HANSEN, HF ;

ROEPSTORFF, P .

BIOCHEMICAL JOURNAL, 1989, 262 (02) :513-519

[7] BETA-ENDORPHIN IS A POTENT ANALGESIC AGENT [J].

LOH, HH ;

TSENG, LF ;

WEI, E ;

LI, CH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (08) :2895-2898

[8]

MARQUARDT H, 1986, J BIOL CHEM, V261, P9727

[9] AMINO-ACID-SEQUENCE OF ACYL-COA-BINDING PROTEIN FROM COW LIVER [J].

MIKKELSEN, J ;

HOJRUP, P ;

NIELSEN, PF ;

ROEPSTORFF, P ;

KNUDSEN, J .

BIOCHEMICAL JOURNAL, 1987, 245 (03) :857-861

[10] PUTATIVE DIAZEPAM BINDING INHIBITOR PEPTIDE - CDNA CLONES FROM RAT [J].

MOCCHETTI, I ;

EINSTEIN, R ;

BROSIUS, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7221-7225