SYNTHESIS OF 4-AMINO HYDROXY-6-METHYLTHIO-1/2-(2',2'-DIETHOXYETHYL)-1H/2H-PYRAZOLO[3,4-D]PYRIMIDINES AND THEIR ANTIALLERGIC ACTIVITY

被引：11

作者：

AVASTHI, K ^{[1
]}

GARG, N ^{[1
]}

CHANDRA, T ^{[1
]}

BHAKUNI, DS ^{[1
]}

GUPTA, PP ^{[1
]}

SRIMAL, RC ^{[1
]}

机构：

[1] CENT DRUG RES INST,DIV INTERNAL MED,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 7-8期

关键词：

4-AMINO HYDROXY-PYRAZOLO[3,4-D]PYRIMIDINES; ANTIALLERGIC ACTIVITY;

D O I：

10.1016/0223-5234(93)90089-W

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of 4-amino/hydroxy-6-substituted- 1/2-(2',2'-diethoxyethyl)-1H/2H-pyrazolo[3,4-d]pyrimidines by alkylation of substituted pyrazolo[3,4-d]pyrimidines has been described, and their antiallergic activity evaluated in mice. The 2 most active compounds 4b and 5b were also tested in the rat. The most active compound 4b showed non-significant antihistaminic or antiserotoninergic activity.

引用

页码：585 / 591

页数：7

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