STIMULANT EFFECT OF HUMAN GAMMA-GLOBULIN ON SMOOTH-MUSCLE PREPARATIONS

被引：1

作者：

ABRAHAMS, Z ^{[1
]}

CHANG, SD ^{[1
]}

SUTTER, MC ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,2176 HLTH SCI MALL,VANCOUVER V6T 1Z3,BC,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 238卷 / 2-3期

关键词：

GAMMA-GLOBULIN (HUMAN); IMMUNOGLOBULINS; SMOOTH MUSCLE; IMMUNOGLOBULIN-G; SPONTANEOUS CONTRACTILITY;

D O I：

10.1016/0014-2999(93)90882-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of human gamma globulin on the contractile activity of spontaneously active rat mesenteric portal vein and guinea-pig taenia caeci and quiescent rat aorta and guinea-pig trachea muscles were studied in vitro. Human gamma globulin significantly increased the contractile activity of the spontaneously active muscles with respect to both amplitude and frequency of contraction whereas it had no significant effect on the contractile activity of guiescent muscle preparations. These findings suggest that immunoglobulins directly modulate smooth muscle including vasculature by modifying the membrane electrical activity associated with the generation of spontaneous activity.

引用

页码：435 / 439

页数：5

共 14 条

[1]

BURTON DR, 1986, IMMUNOGLOBULINS HLTH, P1

[2]

DZIELAK DJ, 1992, HYPERTENSION S1, V19, P136

[3] RAISED SERUM IGG LEVELS IN HYPERTENSION [J].