STRUCTURE-FUNCTION STUDIES ON CYTOSKELETAL PROTEINS IN DICTYOSTELIUM AMEBAS AS A PARADIGM

被引：24

作者：

SCHLEICHER, M ^{[1
]}

ANDRE, B ^{[1
]}

ANDREOLI, C ^{[1
]}

EICHINGER, L ^{[1
]}

HAUGWITZ, M ^{[1
]}

HOFMANN, A ^{[1
]}

KARAKESISOGLOU, J ^{[1
]}

STOCKELHUBER, M ^{[1
]}

NOEGEL, AA ^{[1
]}

机构：

[1] MAX PLANCK INST BIOCHEM,D-82152 MARTINSRIED,GERMANY

来源：

FEBS LETTERS | 1995年 / 369卷 / 01期

关键词：

ACTIN-BINDING PROTEIN; CYTOSKELETON; CELL MOTILITY; DICTYOSTELIUM; MOLECULAR GENETICS;

D O I：

10.1016/0014-5793(95)00579-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The actin cytoskeleton in motile non-muscle cells is being regulated by a large number of actin-binding proteins, A deeper insight into the complex nature of the dynamic rearrangements of the microfilament system during cell movement requires an experimental system that allows the combined application of biochemical, biophysical, cell biological and molecular methods, Dictyostelium amoebae are well suited especially for a genetic approach because they are amenable to gene disruption, antisense and gene tagging techniques, The actin-binding proteins profilin, hisactophilin and protovillin are being described in this context as typical examples that either bind to G-actin, or anchor the actin cytoskeleton to the plasma membrane, or are structurally similar to vertebrate proteins but distinct in their functions.

引用

页码：38 / 42

页数：5

共 48 条

[1] A DICTYOSTELIUM MUTANT DEFICIENT IN SEVERIN, AN F-ACTIN FRAGMENTING PROTEIN, SHOWS NORMAL MOTILITY AND CHEMOTAXIS [J].