METHAEMOGLOBIN FORMATION BY AROMATIC AMINES

被引：46

作者：

MCLEAN, S

STARMER, GA

THOMAS, J

机构：

[1] Department of Pharmacy, University of Sydney, Sydney, New South Wales

[2] Department of Pharmacology, University of Sydney, Sydney, New South Wales

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / 21卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08285.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Methaemoglobin formation induced in cats by many substituted anilines has been investigated in an attempt to correlate chemical structure with activity. Although no precise relation emerged, some generalizations could be made. 4‐Substituents (except methyl and methoxy) increased the activity of aniline. The activity of aniline was either unaltered or reduced by 2‐ and 3‐substituents. Polyhalo‐, polymethyl‐, methoxy‐, ethoxy‐ and carboxyester substituents reduced activity, and carboxy groups abolished it. Steric effects around the amino‐group were not important. The activities of the compounds are discussed in relation to their absorption, distribution, metabolic transformation and the activities of their metabolites. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：441 / +

页数：1

共 39 条

[1] OXIDATIVE HEMOLYSIS AND PRECIPITATION OF HEMOGLOBIN .2. ROLE OF THIOLS IN OXIDANT DRUG ACTION [J].