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DELAYED FIBRIN POLYMERIZATION DUE TO REMOVAL OF CALCIUM IONS

被引：14
作者：
GODAL, HC
机构：
[1] Haematological Research Laboratory, Dept. IX Ullevål Hospital, University Clinic, Oslo
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1969年 / 24卷 / 01期
关键词：
Calcium; EDTA; Polymerization; Thrombin clotting time;
D O I：
10.3109/00365516909080128
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
EDTA inhibits reversibly the thrombin-fibrinogen reaction by a time-dependent effect on fibrinogen. Utilizing the stability of various metal-EDTA complexes, evidence is presented that EDTA acts by chelating traces of essential metal ions, whereas EDTA itself seems inactive. N-terminal analysis revealed that the effect of EDTA on the thrombin-fibrinogen reaction does not involve the enzymatic part of the reaction, but is restricted to the polymerization process. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：29 / &
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