INDUCTION OF SISTER CHROMATID EXCHANGES BY DIHYDRODIOLS DERIVED FROM 7,12-DIMETHYLBENZ[ALPHA]ANTHRACENE AND 3-METHYLCHOLANTHRENE

被引：10

作者：

PAL, K

GROVER, PL

SIMS, P

机构：

[1] The Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, London, SW3 6JB, Fulham Road

来源：

CANCER LETTERS | 1979年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0304-3835(79)80075-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The in vitro induction of sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells by the polycyclic hydrocarbons, 7,12-dimethylbenz[a]anthracene and 3-methylcholanthrene and some of the related dihydrodiols was investigated. Increased numbers of SCEs were seen in the chromosomes of cells exposed to non-K-region dihydrodiols. The most active compounds were the 3,4-dihydrodiol of 7,12-dimethylbenz[a]anthracene and the 7,8- and 9,10-dihydrodiols of 3-methylcholanthrene: the parent hydrocarbons and their corresponding K-region dihydrodiols were relatively less active. The results are consistent with others that suggest that the metabolic activation of both hydrocarbons proceeds through the conversion of non-K-region dihydrodiols into vicinal diol-epoxides. © 1979 Elsevier/North-Holland Scientific Publishers Ltd., All rights reserved.

引用

页码：45 / 49

页数：5

共 7 条

[1] 8,9-DIHYDRO-8,9-DIHYDROXYBENZ(A)ANTHRACENE 10,11-OXIDE - NEW TYPE OF POLYCYCLIC AROMATIC HYDROCARBON METABOLITE [J].

BOOTH, J ;

SIMS, P .

FEBS LETTERS, 1974, 47 (01) :30-33

[2]

JERINA DM, 1976, IN VITRO METABOLIC A, P159

[3] MICROSOME-MEDIATED MUTAGENICITIES OF DIHYDRODIOLS OF 7,12-DIMETHYLBENZ[A]ANTHRACENE - HIGH MUTAGENIC ACTIVITY OF 3,4-DIHYDRODIOL [J].

MALAVEILLE, C ;

BARTSCH, H ;

TIERNEY, B ;

GROVER, PL ;

SIMS, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 83 (04) :1468-1473

[4]

MALEVEILLE C, BIOCH BIOPHYS RES CO

[5] INDUCTION OF MALIGNANT TRANSFORMATION AND MUTAGENESIS BY DIHYDRODIOLS DERIVED FROM 7,12-DIMETHYLBENZ[A]ANTHRACENE [J].

MARQUARDT, H ;

BAKER, S ;

TIERNEY, B ;

GROVER, PL ;

SIMS, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 85 (01) :357-362

[6] INDUCTION OF SISTER-CHROMATID EXCHANGES IN CHINESE-HAMSTER OVARY CELLS TREATED INVITRO WITH NON-K-REGION DIHYDRODIOLS OF 7-METHYLBENZO[A]PYRENE [J].

PAL, K ;

TIERNEY, B ;

GROVER, PL ;

SIMS, P .

MUTATION RESEARCH, 1978, 50 (03) :367-375

[7] METABOLIC ACTIVATION OF BENZO(A)PYRENE PROCEEDS BY A DIOL-EPOXIDE [J].

SIMS, P ;

GROVER, PL ;

SWAISLAN.A ;

PAL, K ;

HEWER, A .

NATURE, 1974, 252 (5481) :326-328

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