EFFECTS OF ETHIONINE ON TRANSFER-RNA METHYLATION IN MALE AND FEMALE RATS

被引：4

作者：

WAINFAN, E ^{[1
]}

BALIS, ME ^{[1
]}

机构：

[1] SLOAN KETTERING INST CANC RES,NEW YORK,NY 10021

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91895-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Administration of hepatocarcinogens to rats results in an increase in tRNA methyltransferase activity in the target tissues. Ethionine is active as a carcinogen only in female rats and only in females is this increase in enzyme activity seen. However, ethionine also causes the formation of methyl-deficient tRNA in the liver. Other hepatocarcinogens do not do this. Ethionine is equally effective in this action in males and females. Thus, the two actions of ethionine are completely separable, and the methyl-deficiency of tRNA is caused by an activity not identical with the carcinogenic one. © 1979.

引用

页码：777 / 782

页数：6

共 9 条

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[2]

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[4]

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[5] TRANSFER RNA METHYLASES OF HUMAN LYMPHOCYTES .1. INDUCTION BY PHA IN NORMAL LYMPHOCYTES [J].

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[6] PROPERTIES OF SOLUBLE RIBONUCLEIC ACID METHYLASES FROM RAT LIVER [J].

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[7]

WAINFAN E, 1978, CANCER RES, V38, P1852

[8]

WAINFAN E, 1975, CANCER RES, V35, P2830

[9]

WAINFAN E, 1977, CANCER RES, V37, P865

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