TUMOR UPTAKE OF RADIOLABELED PYRIMIDINE-BASES AND PYRIMIDINE NUCLEOSIDES IN ANIMAL-MODELS .2. 6-[H-3]-5-FLUORO-2'-DEOXYURIDINE

被引：2

作者：

ABRAMS, DN ^{[1
]}

KNAUS, EE ^{[1
]}

LENTLE, BC ^{[1
]}

WIEBE, LI ^{[1
]}

机构：

[1] UNIV ALBERTA,DIV BIONUCLEON & RADIOPHARM,EDMONTON T6G 2N8,ALBERTA,CANADA

来源：

INTERNATIONAL JOURNAL OF NUCLEAR MEDICINE & BIOLOGY | 1979年 / 6卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0047-0740(79)90004-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The short-term differential distribution of 6-[3H]-5-fluoro-2′-deoxyuridine (6-[3H]-5-FUdR) has been studied in vivo in the Ehrlich Ascites carcinoma (EACa) and Lewis Lung carcinoma (LLCa) tumor models in mice. Significant uptake of the nucleoside by the spleen, bone marrow, gastrointestinal tract and liver were observed, along with tumor:blood ratios of radioactivity in the region of 50:1. The maximum uptake of 6-[3H]-5-FUdR by the EACa and LLCa tumors represented 4.3% and 5.3% of the dose respectively. Approximately 60% of the administered dose was excreted in the urine within 6 h, and 80% of the dose was present in 72 h urine. Analysis of excretion data indicated that the fast elimination component half-times were 3.8 h (EACa) and 1.1 h (LLCa). Respective slow component half-times were 49 and 80 h. © 1979.

引用

页码：103 / 107

页数：5

共 9 条

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INTERNATIONAL JOURNAL OF NUCLEAR MEDICINE & BIOLOGY, 1979, 6 (02) :97-101

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INTERNATIONAL JOURNAL OF NUCLEAR MEDICINE & BIOLOGY, 1976, 3 (3-4) :134-137

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