INCREASED SOD ACTIVITIES AND DECREASED LIPID PEROXIDE LEVELS INDUCED BY LOW-DOSE X-IRRADIATION IN RAT ORGANS

被引：113

作者：

YAMAOKA, K ^{[1
]}

EDAMATSU, R ^{[1
]}

MORI, A ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,INST NEUROBIOL,DEPT NEUROCHEM,2-5-1 SHIKATA CHO,OKAYAMA 700,JAPAN

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1991年 / 11卷 / 03期

关键词：

LOW DOSE IRRADIATION; INDUCTION OF SOD; DECREASE IN LIPID PEROXIDES; FREE RADICALS;

D O I：

10.1016/0891-5849(91)90127-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p < 0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.

引用

页码：299 / 306

页数：8

共 15 条

[1]

Bartosz, Leyko, Fried, Is superoxide dismutase a physiological radioprotector, Experientia, 35, (1979)

[2]

Kimball, Reddy, Peirce, Schwartz, Mustafa, Cross, Oxygen toxicity: augumentation of antioxidant defense mechanisms in rat lung, Am. J. Physiol., 230, 5, pp. 1425-1431, (1976)

[3]

Shiraishi, Aono, Utsumi, Increased metallothionein content in rat liver induced by X-irradiation and exposure to high oxygen tenson, Radiation Res., 95, pp. 298-302, (1983)

[4]

Paynter, The role of dietary copper, manganese, selenium and vitamin E in lipid peroxidation in tissues of the rat, Biol. Trace Element Res., 2, pp. 121-135, (1980)

[5]

Petkau, Role of superoxide dismutase in modification of radiation injury, Br. J. Cancer Supplement, 8, pp. 87-95, (1987)

[6]

Yamaoka, Kaneko, Mizutani, Nakano, Edamatsu, Mori, Basic study on low dose radiation effects: SOD activities of immune organs and homograms in rats, CRIEPI Report: T89002, (1989)

[7]

Yamaoka, Edamatsu, Mori, SOD activities and lipid peroxides in brains, livers, and immune organs of rats by low dose radiation, J. Radiat. Res., 1, (1990)

[8]

Yamaoka, Edamatsu, Mori, SOD activities and lipid peroxides in brains, livers, and immune organs of rats by low dose radiation, J. Radiat. Res., 1, (1990)

[9]

Feinendegen, Muhlensiepen, Biochemical and cellular mechanisms of low-dose effects, Int. J. Radiat. Biol., 53, pp. 23-37, (1988)

[10]

Hiramatsu, Kohno, Development of superoxide dismutase assay methods using ESR, JOEL News, 26, 6, pp. 106-109, (1986)

← 1 2 →