HLA-DQA1, HLA-DQB1 AND HLA-DRB1 GENOTYPING IN JAPANESE PEMPHIGUS-VULGARIS PATIENTS BY THE PCR-RFLP METHOD

被引：44

作者：

NIIZEKI, H

INOKO, H

MIZUKI, N

INAMOTO, N

WATABABE, K

HASHIMOTO, T

NISHIKAWA, T

机构：

[1] KEIO UNIV,SCH MED,DEPT DERMATOL,SHINJUKU KU,TOKYO 160,JAPAN

[2] TOKAI UNIV,SCH MED,DEPT GENET INFORMAT,DIV MOLEC LIFE SCI,TOKAI,IBARAKI,JAPAN

[3] KITASATO INST HOSP,DERMATOL SECT,TOKYO,JAPAN

来源：

TISSUE ANTIGENS | 1994年 / 44卷 / 04期

关键词：

HLA-DQ; HLA-DR; PEMPHIGUS VULGARIS; JAPANESE; PCR-RFLP;

D O I：

10.1111/j.1399-0039.1994.tb02390.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We performed HLA-DQA1, -DQB1 and -DRB1 genotyping using the PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method for 32 Japanese pemphigus vulgaris (PV) patients. There was a significant association of either DQB1*0503 or DRB1*1405 with PV, and a negative association of either DQA1*0103 or DQB1*0601 with PV was found. Since the DQB1*0503(+) patients had various DR14-related alleles, we concluded that the association with DQB1 is primary and that the association with DRB1 is simply due to linkage disequilibrium between the DQ and DR genes. These results may indicate that specific HLA class II antigens confer the susceptibility to PV among Japanese.

引用

页码：248 / 251

页数：4

共 17 条

[1] AUTOANTIBODIES AGAINST THE AMINO-TERMINAL CADHERIN-LIKE BINDING DOMAIN OF PEMPHIGUS-VULGARIS ANTIGEN ARE PATHOGENIC [J].