CHARACTERISTICS OF ATRIAL REENTRY AND MEANDER COMPUTED FROM A MODEL OF A RABBIT SINGLE ATRIAL CELL

被引：20

作者：

HOLDEN, AV ^{[1
]}

ZHANG, H ^{[1
]}

机构：

[1] UNIV LEEDS,CTR NONLINEAR STUDIES,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

JOURNAL OF THEORETICAL BIOLOGY | 1995年 / 175卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/jtbi.1995.0162

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A two-dimensional excitable medium model of atrial tissue has been constructed by incorporating the Earm-Hilgemann-Noble excitation equations for membrane voltage-dependent ionic currents and pump exchanger currents, time-dependent changes in intracellular and extracellular ionic concentrations, and storage and release of Ca2+, for an atrial cell in an homogeneous partial differential equation. A diffusion coefficient of 1.25 cm(2) sec(-1) gives the conduction velocity of a solitary planar wave as 0.6 m sec(-1). A spiral wave with a period of 78 msec develops from a broken wavefront, and initially rotates around a circular core of 2 mm diameter. After 1.5 sec of rotation, a biperiodic meander, with 6 epicycles/cycle, develops. This simple meander pattern is reflected in a period-6 modulation of the intervals between successive wavefronts. (C) 1995 Academic Press Limited

引用

页码：545 / 551

页数：7

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