ISOLATION OF A REVERTANT CLONE FROM A VARIANT EMBRYONAL CARCINOMA CELL-LINE DEFICIENT IN METABOLIC COOPERATION

被引：9

作者：

HOOPER, ML

MORGAN, RHM

机构：

[1] Cancer Research Campaign Cell Genetics Group, Institute of Genetics, Glasgow

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 123卷 / 02期

关键词：

D O I：

10.1016/0014-4827(79)90484-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A revertant clone with restored capacity for metabolic cooperation has been isolated from the cooperation-defective variant embryonal carcinoma cell line R5/3. The properties of the revertant clone provide evidence that deficiencies shown by R5/3 in intercellular transfer of nucleotides and sodium ions are the result of a common genetic lesion which can be dissociated from a secondary lesion causing increased thioguanine resistance and from an increase in ploidy. © 1979.

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页码：392 / 396

页数：5

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