STIMULATION OF THE HEXOSE-MONOPHOSPHATE PENTOSE PATHWAY BY DELTA-1-PYRROLINE-5-CARBOXYLIC ACID IN HUMAN-FIBROBLASTS

被引：36

作者：

PHANG, JM

DOWNING, SJ

YEH, GC

SMITH, RJ

WILLIAMS, JA

机构：

[1] Endocrine Section, Metabolism Branch, National Cancer Institute, Bethesda

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91805-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

L-pyrroline-5-carboxylic acid, an intermediate in the interconversions of glutamic acid, ornithine and proline, is a potent stimulator of the hexose-monophosphate pentose pathway in cultured human fibroblasts. These studies suggest that pyrroline-5-carboxylate reductase, which catalyzes the conversion of pyrroline-5-carboxylate to proline coupled with the oxidation of NADPH, provides the NADP for the observed activation of the hexose-monophosphate pentose pathway. © 1979.

引用

页码：363 / 370

页数：8

共 32 条

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