NUCLEOTIDE-SEQUENCE OF THE LYS2 GENE OF SACCHAROMYCES-CEREVISIAE - HOMOLOGY TO BACILLUS-BREVIS TYROCIDINE SYNTHETASE-1

被引：55

作者：

MORRIS, ME ^{[1
]}

JINKSROBERTSON, S ^{[1
]}

机构：

[1] EMORY UNIV,DEPT BIOL,1510 CLIFTON RD,ATLANTA,GA 30322

来源：

GENE | 1991年 / 98卷 / 01期

关键词：

RECOMBINANT DNA; LYSINE; YEAST; ALPHA-AMINOADIPATE REDUCTASE; TYROCIDINE; ANTIBIOTIC SYNTHESIS;

D O I：

10.1016/0378-1119(91)90117-T

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Saccharomyces cerevisiae LYS2 gene, which encodes alpha-aminoadipate reductase, an essential enzyme in the yeast lysine biosynthetic pathway, has been sequenced. A large open reading frame (ORF) has been identified which can specify a 1392-amino acid protein with a deduced M(r) of 155 344. A DNA database search using the translated LYS2 ORF as a probe has revealed significant aa sequence homology to the Bacillus brevis enzyme tyrocidine synthetase 1.

引用

页码：141 / 145

页数：5

共 21 条

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