DETERMINATION OF BETA-CARBOLINES IN FOODSTUFFS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：83

作者：

ADACHI, J ^{[1
]}

MIZOI, Y ^{[1
]}

NAITO, T ^{[1
]}

YAMAMOTO, K ^{[1
]}

FUJIWARA, S ^{[1
]}

NINOMIYA, I ^{[1
]}

机构：

[1] KOBE WOMENS COLL PHARM,KOBE 658,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 538卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(01)88854-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method combined with fluorimetric detection is described for the determination of beta-carboline (norharman) and 1-methyl-beta-carboline (harman). The analysis of foodstuffs for the identification of beta-carbolines is facilitated by clean-up of samples using Bond Elut PRS cartridges. Recoveries were excellent. Further, a high-performance liquid chromatographic-mass spectrometric method was also developed for their identification. The concentrations of beta-carboline among the foodstuffs and alcoholic beverages varied greatly. Also, norharman and harman were observed in uncooked foodstuffs, whereas acetaldehyde was found in most fermented food. The toxicological implication of beta-carbolines in foodstuffs is discussed.

引用

页码：331 / 339

页数：9

共 10 条

[1] HARMAN IN ALCOHOLIC BEVERAGES - PHARMACOLOGICAL AND TOXICOLOGICAL IMPLICATIONS [J].