REGULATORY ELEMENTS THAT CONTROL THE LINEAGE-SPECIFIC EXPRESSION OF MYOD

被引:138
作者
GOLDHAMER, DJ
FAERMAN, A
SHANI, M
EMERSON, CP
机构
[1] FOX CHASE CANC INST, INST CANC RES, PHILADELPHIA, PA 19111 USA
[2] VOLCANI CTR, INST ANIM SCI, IL-50250 BET DAGAN, ISRAEL
关键词
D O I
10.1126/science.1315077
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The molecular basis of skeletal muscle lineage determination was investigated by analyzing DNA control elements that regulate the myogenic determination gene myoD. A distal enhancer was identified that positively regulates expression of the human myoD gene. The myoD enhancer and promoter were active in myogenic and several nonmyogenic cell lines. In transgenic mouse embryos, however, the myoD enhancer and promoter together directed expression of a lacZ transgene specifically to the skeletal muscle lineage. These data suggest that during development myoD is regulated by mechanisms that restrict accessibility of myoD control elements to positive trans-acting factors.
引用
收藏
页码:538 / 542
页数:5
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