EVIDENCE FOR A ROLE OF AN INTRACARDIAC RENIN-ANGIOTENSIN SYSTEM IN NORMAL AND FAILING HEARTS

被引：77

作者：

DOSTAL, DE

BAKER, KM

机构：

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/1050-1738(93)90039-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The renin-angiotensin system is recognized as an important hormonal regulator of cardiovascular homeostasis. The effectiveness of converting enzyme inhibitors in the treatment of heart failure has stimulated interest in the importance of the renin-angiotensin system. Recent biochemical, molecular biological, and functional evidence suggests the presence and regulated synthesis of renin-angiotensin system components in the heart. In the normal heart, locally derived angiotensin II may modulate coronary blood flow, inotropy, and chronotropy, whereas under pathologic conditions the cardiac renin-angiotensin system may influence ventricular growth and myocardial metabolism, induce ventricular arrhythmias during ischemia and reperfusion-induced myocardial injury, and contribute to postinfarction ventricular remodeling.

引用

页码：67 / 74

页数：8

共 52 条

[1] [SAR1]ANGIOTENSIN-2 RECEPTOR-MEDIATED STIMULATION OF PROTEIN-SYNTHESIS IN CHICK HEART-CELLS [J].