DIASTEREOSELECTIVE SYNTHESIS OF 2,5-DIALKYL TETRAHYDROFURAN-3-ONES BY A COPPER-CATALYZED TANDEM CARBENOID INSERTION AND YLIDE REARRANGEMENT REACTION

被引：72

作者：

CLARK, JS

机构：

[1] Department of Chemistry, University of Nottingham, Nottingham

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(00)60041-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cu(acac)2-Catalysed cyclisations of the alpha-diazo ketones 3, result in the diastereoselective formation (>97:3) of the trans-2,5-dialkyl tetrahydrofuran-3-ones 4. The yields and levels of diastereoselection are catalyst, solvent, and temperature dependent.

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页码：6193 / 6196

页数：4

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