CLOSED CIRCULAR DNA AS A PROBE FOR PROTEIN-INDUCED STRUCTURAL-CHANGES

被引：19

作者：

WHITE, JH

GALLO, RM

BAUER, WR

机构：

[1] SUNY STONY BROOK,DEPT MICROBIOL,STONY BROOK,NY 11794

[2] SUNY STONY BROOK,GRAD PROGRAM MOLEC BIOL & BIOCHEM,STONY BROOK,NY 11794

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 01期

关键词：

D O I：

10.1016/0968-0004(92)90417-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biological systems are replete with examples of DNA formed into a closed loop structure, either alone or in close association with proteins. Such closed circular DNA molecules are subject to a topological constraint that modifies, often in a major way, the structure and reactivity of the DNA. The topological constraint also permits closed circular DNAs to be used as analytical tools to learn about the structure of DNA-protein complexes.

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页码：7 / 12

页数：6

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