MINOR-GROOVE BINDERS ARE INHIBITORS OF THE CATALYTIC ACTIVITY OF DNA GYRASES

被引：41

作者：

STORL, K ^{[1
]}

STORL, J ^{[1
]}

ZIMMER, C ^{[1
]}

LOWN, JW ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2E1,ALBERTA,CANADA

来源：

FEBS LETTERS | 1993年 / 317卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

DNA BINDING DRUG; INHIBITION; DNA GYRASE; STREPTOMYCES-NOURSEI;

D O I：

10.1016/0014-5793(93)81513-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-intercalating DNA minor-groove binders may effectively inhibit the supercoiling activity of gyrases by influencing the enzyme recognition and cleavage site on DNA. For gyrase from Streptomyces noursei a wide range of inhibitory potency for different classes of ligands is observed. This can be explained by a number of structural and binding factors of the ligands competing with the gyrase on the target site of DNA, the mechanism of which is different from the classical gyrase inhibitors.

引用

页码：157 / 162

页数：6

共 40 条

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