BIOSYNTHESIS OF COLLETODIOL AND RELATED POLYKETIDE MACRODIOLIDES IN CYTOSPORA SP - ATCC 20502 - SYNTHESIS AND METABOLISM OF ADVANCED INTERMEDIATES

被引：22

作者：

ONEILL, JA ^{[1
]}

SIMPSON, TJ ^{[1
]}

WILLIS, CL ^{[1
]}

机构：

[1] UNIV BRISTOL,SCH CHEM,CANTOCKS CLOSE,BRISTOL BS8 1TS,AVON,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 09期

关键词：

D O I：

10.1039/c39930000738

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The triene 3 and epoxide 6 have been synthesised in specifically labelled form and their incorporation into the macrodiolide, colletodiol 1 demonstrated in cultures of Cytospora sp. ATCC 20502; results of a biomimetic reaction indicate that both colletoketol 2 and grahamimycin A1 7 may be biosynthesised in a single oxidation step from colletodiol.

引用

页码：738 / 740

页数：3

共 20 条

[1] SULFOXONIUM SALTS AS REAGENTS FOR OXIDATION OF PRIMARY AND SECONDARY ALCOHOLS TO CARBONYL-COMPOUNDS
ALBRIGHT, JD
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1974, 39 (13) : 1977 - 1979
[2] REVISED STRUCTURE OF THE MACRODIOLIDE COLLETODIOL
AMSTUTZ, R
HUNGERBUHLER, E
SEEBACH, D
[J]. HELVETICA CHIMICA ACTA, 1981, 64 (06) : 1796 - 1799
[3] BALDWIN JE, 1992, SYNLETT, P875
[4] BOCKMAN R, 1974, J AM CHEM SOC, V96, P5954
[5] TOTAL SYNTHESIS OF THE MACRODIOLIDE PYRENOPHOROL
DOMMERHOLT, FJ
THIJS, L
ZWANENBURG, B
[J]. TETRAHEDRON LETTERS, 1991, 32 (11) : 1499 - 1502
[6] AN ENANTIOSELECTIVE TOTAL SYNTHESIS OF THE MACRODIOLIDE (-)-(RRR)-COLLETALLOL
DOMMERHOLT, FJ
THIJS, L
ZWANENBURG, B
[J]. TETRAHEDRON LETTERS, 1991, 32 (11) : 1495 - 1498
[7] GAREGG PJ, 1979, SYNTHESIS-STUTTGART, P469
[8] GUNTER C, UNPUB
[9] GURUSIDDAIAH S, 1981, ANTIMICROB AGENTS CH, V19, P1953
[10] TOTAL SYNTHESIS OF (-)-GRAHAMIMYCIN-A1
HILLIS, LR
RONALD, RC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (04) : 470 - 473

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