CHRONIC TOXICITY OF 2,3,7,8-TETRACHLORODIBENZOFURAN FOR RHESUS MACAQUES

被引：16

作者：

MCNULTY, WP ^{[1
]}

POMERANTZ, I ^{[1
]}

FARRELL, T ^{[1
]}

机构：

[1] US FDA, DIV CHEM TECHNOL, WASHINGTON, DC 20204 USA

来源：

FOOD AND COSMETICS TOXICOLOGY | 1981年 / 19卷 / 01期

关键词：

D O I：

10.1016/0015-6264(81)90304-7

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

2,3,7,8-Tetrachlorodibenzofuran [a contaminant in the wood preservative pentachlorophenol and in polychlorinated biphenyls; TCDF] at levels of 50 and 5 .mu.g/kg (ppb) in food caused sickness and some deaths in groups of 3 rhesus macaques fed for 2 mo. and 6 mo., respectively. The principal pathological changes were atrophy or squamous metaplasia of the sebaceous glands, mucous metaplasia and hyperplasia of the gastric mucosa, involution of the thymus and hypoplasia of the bone marrow. In animals that did not die during the experimental feeding, recovery was complete after 3 mo. of a TCDF-free diet.

引用

页码：57 / +

共 28 条

[1] MORPHOLOGICAL-CHANGES IN MONKEYS CONSUMING A DIET CONTAINING LOW-LEVELS OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN [J].