CLONING AND SEQUENCE OF THE CDNA-ENCODING THE RAT OLIGODENDROCYTE INTEGRIN BETA(1) SUBUNIT

被引：18

作者：

MALEKHEDAYAT, S

ROME, LH

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT BIOL CHEM,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,MENTAL RETARDAT RES CTR,LOS ANGELES,CA 90024

来源：

GENE | 1995年 / 158卷 / 02期

关键词：

CELL-SURFACE GLYCOPROTEIN; FIBRONECTIN RECEPTOR; AMINO ACID SEQUENCE HOMOLOGY; BETA(OL);

D O I：

10.1016/0378-1119(94)00911-B

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have isolated a cDNA clone encoding an integrin (Itg) beta-subunit polypeptide from a rat cerebral cortex oligodendroglia cDNA library. This beta-subunit was previously designated beta(OL) (OL for oligodendroglia), since it had an M(r) that differed from that of the rat fibroblast beta(1) protein. The complete nucleotide sequence encoding the signal sequence and mature protein was determined. Comparison of the deduced amino acid (aa) sequence of beta(OL) to those of integrin beta subunits from other species revealed that beta(OL) is a member of the integrin (Itg) beta(1) class. The aa sequence of beta(OL) shows 78.5-97.9% similarity to beta(1) chains from four other species and displays all the features characteristic of the Itg beta subunits, indicating the high degree of structural conservation seen in this subunit of the Itg receptors.

引用

页码：287 / 290

页数：4

共 9 条

[1] AMINO-ACID-SEQUENCE OF THE HUMAN FIBRONECTIN RECEPTOR [J].