SELECTIVE LOSS OF NADPH-DIAPHORASE-CONTAINING NEURONS IN THE DENTATE GYRUS FOLLOWING TRANSIENT ISCHEMIA

被引：11

作者：

HONG, SC ^{[1
]}

LANZINO, G ^{[1
]}

COLLINS, J ^{[1
]}

KASSELL, NF ^{[1
]}

LEE, KS ^{[1
]}

机构：

[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROL SURG,CHARLOTTESVILLE,VA 22908

来源：

NEUROREPORT | 1993年 / 5卷 / 01期

关键词：

NITRIC OXIDE SYNTHASE; DENTATE GYRUS; ISCHEMIA; SELECTIVE VULNERABILITY;

D O I：

10.1097/00001756-199310000-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effect of transient forebrain ischemia on NADPH-diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50% compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.

引用

页码：84 / 86

页数：3

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