EFFECTS OF H1-RECEPTOR AND H2-RECEPTOR AGONISTS AND ANTAGONISTS ON TOTAL LUNG RESISTANCE, DYNAMIC LUNG COMPLIANCE AND IRRITANT RECEPTOR DISCHARGE IN THE ANESTHETIZED DOG

被引:25
作者
DIXON, M
JACKSON, DM
RICHARDS, IM
机构
[1] Department of Pharmacology, Research and Development Laboratories, Fisons Ltd, Loughborough, Leicestershire
关键词
D O I
10.1111/j.1476-5381.1979.tb13666.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of histamine and 4 methylhistamine (i.v.) alone, and in the presence of chlorpheniramine or cimetidine, on total lung resistance (RL), dynamic lung compliance (Cdyn) and irritant receptor activity have been studied in dogs anaesthetized with chloralose. Histamine produced dose‐related increases in RL and irritant receptor activity with associated falls in Cdyn which were blocked by chlorpheniramine but unaffected by cimetidine. 4 Methylhistamine produced small insignificant changes in R1 and Cdyn and small significant increases in irritant receptor activity which were reduced with chlorpheniramine but unaffected by cimetidine. The results suggest that histamine increases irritant receptor activity, either directly or indirectly, via H1‐receptors. 1979 British Pharmacological Society
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页码:203 / 209
页数:7
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