INFLUENCE OF TEMPERATURE ON THE SENSITIVITY OF THE ADRENOCEPTORS IN THE ISOLATED ATRIA OF GUINEA-PIGS AND RATS

被引：21

作者：

MORI, K ^{[1
]}

HASHIMOTO, H ^{[1
]}

HASEGAWA, H ^{[1
]}

NAKASHIMA, M ^{[1
]}

机构：

[1] NAGOYA TEISHIN HOSP,DEPT PHARM,NAGOYA,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 55卷 / 02期

关键词：

Cardiac adrenoceptors; Isolated atria; Isoproterenol; Phenylephrine; Positive inotropic effect; Temperature;

D O I：

10.1016/0014-2999(79)90391-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of the bath temeprature on the responsiveness to sympathomimetic amines was studied with isolated guinea pig and rat atria. In electrically driven guinea pig left atria, the dose-response curve for the positive inotropic effect of isoproterenol (ISO) was shifted to the left by lowering the temperature from 36 to 24°C. The positive inotropic effect of phenylephrine (PHE) in lower concentrations was attenuated by lowering the temperature. Phenotalamine markedly inhibited the PHE response at 36 and 32°C, whereas it produced no inhibition at 24°C. Similar changes were observed with rat left atria. In guinea pig left atria, propanolol inhibited the responses to PHE more effectively at 24°C than at 32°C. With guinea pig and rat atria the dose-response curve for the positive inotropic effect of PHE in the presence of phenotolamine was shifted to the left by lowering the temperature. The results suggest that lowering the temperature of the bath solution diminished the positive inotrropic effect of PHE mediated by α-adrenoceptors and potentiated that mediated by β-adrenoceptors. © 1979.

引用

页码：189 / 197

页数：9

共 31 条

[1] TEMPERATURE-DEPENDENCE OF PHENOXYBENZAMINE EFFECTS AND ADRENOCEPTOR TRANSFORMATION HYPOTHESIS [J].

BENFEY, BG .

NATURE, 1975, 256 (5520) :745-747

[2] CARDIAC ADRENOCEPTORS AT LOW-TEMPERATURE AND ADRENOCEPTOR INTERCONVERSION HYPOTHESIS [J].

BENFEY, BG .

BRITISH JOURNAL OF PHARMACOLOGY, 1977, 61 (02) :167-173

[3] LACK OF RELATIONSHIP BETWEEN MYOCARDIAL CYCLIC AMP CONCENTRATIONS AND INOTROPIC EFFECTS OF SYMPATHOMIMETIC AMINES [J].

BENFEY, BG .

BRITISH JOURNAL OF PHARMACOLOGY, 1971, 43 (04) :757-&

[4]

BENFEY BG, 1973, 9TH INT C BIOCH STOC, P354

[5] LACK OF EVIDENCE FOR A TEMPERATURE-MEDIATED CHANGE OF ADRENOCEPTOR TYPE IN RAT-HEART [J].

BENNETT, T ;

KEMP, PA .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 301 (03) :217-222

[6] TEMPERATURE MODULATION OF ALPHA-ADRENOCEPTORS AND BETA-ADRENOCEPTORS IN ISOLATED FROG HEART [J].

BUCKLEY, GA ;

JORDAN, CC .

BRITISH JOURNAL OF PHARMACOLOGY, 1970, 38 (02) :394-&

[7] KINETICS OF CYCLIC ADENOSINE MONOPHOSPHATE CHANGES IN RAT HEART FOLLOWING EPINEPHRINE ADMINISTRATION [J].

CHEUNG, WY ;

WILLIAMSON, JR .

NATURE, 1965, 207 (5000) :979-+

[8] INFLUENCE OF TEMPERATURE UPON RESERPINE-INDUCED SUPERSENSITIVITY OF GUINEA-PIG ISOLATED ATRIA TO ISOPRENALINE AND SALBUTAMOL [J].

DUNCAN, C ;

BROADLEY, KJ .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1977, 297 (02) :163-170

[9] RELATIONSHIP BETWEEN LEVEL OF CAMP AND CONTRACTILE-FORCE UNDER STIMULATION OF ALPHA-ADRENOCEPTORS AND BETA-ADRENOCEPTORS BY PHENYLEPHRINE IN ISOLATED RABBIT PAPILLARY-MUSCLE [J].

ENDOH, M ;

BRODDE, OE ;

SCHUMANN, HJ .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1976, 295 (02) :109-115

[10]

ENDOH M, 1977, ARCH INT PHARMACOD T, V228, P213

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