SYNTHESIS OF THE HUMAN PROINSULIN SEQUENCE 71-86, .3. SYNTHESIS VIA THE FRAGMENTS 71-78 AND 79-86

被引：7

作者：

BERNDT, H ^{[1
]}

机构：

[1] RHEIN WESTFAL TH AACHEN, DEUTSCH WOLLFORSCH INST, D-5100 AACHEN, FED REP GER

来源：

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE | 1979年 / 360卷 / 06期

关键词：

Human proinsulin; insulin A-chain fragments; peptide purification; peptide synthesis; thiol protection;

D O I：

10.1515/bchm2.1979.360.1.765

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis of the sequence 71-86 of human proinsulin (sequence 6-21 of human insulin A-chain) via fragments 71-78 and 79-86 is described. Good solubility of protected peptide derivatives belonging to sequences 75-78, 79-86 and 71-78 and of fragment 71-86 itself in organic solvents allows quick and efficient purification of these derivatives by liquid chromatography on silica-gel columns.

引用

页码：765 / 772

页数：8

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