INHIBITORY EFFECT OF KANAMYCIN ON EVOKED TRANSMITTER RELEASE - REVERSAL BY 3,4-DIAMINOPYRIDINE

The effect of kenamycin (Kn) on evoked transmitter release was examined in frog end-plates in vitro. By a presynaptic action, Kn (0.02 to 1 mM) significantly reduced the amount of acetylcholine liberated by nerve stimulation. In addition to its presynaptic effects, Kn (0.96 mM) decreased the size of the miniature end-plate potentials possibly by acting at the postsynaptic level. 3,4-Diaminopyridine (4.5μM) reversed the presynaptic effects of Kn but did not modify its postsynaptic action. © 1979.