TRANSIENT EXPRESSION OF TRISOMY-21 AND MONOSOMY-7 FOLLOWING CYCLOSPORINE-A IN A PATIENT WITH APLASTIC-ANEMIA

被引：14

作者：

BARRIOS, NJ ^{[1
]}

KIRKPATRICK, DV ^{[1
]}

LEVIN, ML ^{[1
]}

VARELA, M ^{[1
]}

机构：

[1] TULANE UNIV, SCH MED, HUMAN GENET PROGRAM, NEW ORLEANS, LA 70112 USA

来源：

LEUKEMIA RESEARCH | 1991年 / 15卷 / 06期

关键词：

D O I：

10.1016/0145-2126(91)90065-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present a patient with severe idiopathic aplastic anemia with no previous chromosomal abnormalities who developed trisomy 21 and monosomy 7 during treatment with intravenous (i.v.) cyclosporine. The abnormal karyotype disappeared when the drug was changed to the oral form. This cytogenetic aberration, previously unreported in association with cyclosporine, may reflect either a direct drug effect or the emergence of a hidden myelodysplastic cell clone subject to preferential survival during immunosuppression.

引用

页码：531 / 533

页数：3

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