NATURAL-KILLER (NK) CELLS IN HTLV-I-ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS - DECREASE IN NK CELL SUBSET POPULATIONS AND ACTIVITY IN HTLV-I SEROPOSITIVE INDIVIDUALS

被引:44
作者
YU, F [1 ]
ITOYAMA, Y [1 ]
FUJIHARA, K [1 ]
GOTO, I [1 ]
机构
[1] KYUSHU UNIV 60,INST NEUROL,DEPT NEUROL,FUKUOKA 812,JAPAN
关键词
HUMAN T-LYMPHOTROPIC VIRUS TYPE-I (HTLV-I) ASSOCIATED; MYELOPATHY/TROPICAL SPASTIC PARAPARESIS; NATURAL KILLER CELL; LYMPHOCYTE SUBSET; MONOCLONAL ANTIBODY;
D O I
10.1016/0165-5728(91)90056-D
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We examined natural killer (NK) cell activity and NK cell subset populations in 18 patients with HTLV-I associated myelopathy (HAM)/tropical spastic paraparesis (TSP), ten HTLV-I seropositive asymptomatic carriers and 20 seronegative healthy controls. The NK cell activity was significantly decreased in HAM/TSP, compared with that in controls. The percentages of NK cell subsets, such as CD16+, CD11b+, CD56+, CD16+CD56-, CD16-CD56+, CD16+CD8-, or CD16+CD3+ cells were significantly decreased in HAM/TSP patients. Of particular interest is that the percentage of CD16+CD3+ cells, which have a wide spectrum of cytotoxic properties commonly seen in NK, lymphokine activated killer (LAK) and antibody-dependent cellular-cytotoxic (ADCC) effector cells, was significantly decreased in HAM/TSP as compared to asymptomatic carriers as well as controls. The percentage of CD16+CD3+ cells correlated inversely with the value of spontaneous proliferation of peripheral blood lymphocytes (SPP), which is a characteristic change observed in HAM/TSP.
引用
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页码:121 / 128
页数:8
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