GALANIN-EVOKED ACETYLCHOLINE-RELEASE IN THE RAT STRIATUM IS BLOCKED BY THE PUTATIVE GALANIN ANTAGONIST M15

被引：23

作者：

PRAMANIK, A

OGREN, SO

机构：

[1] Department of Histology and Neurobiology, Karolinska Institute, Stockholm

来源：

BRAIN RESEARCH | 1992年 / 574卷 / 1-2期

关键词：

MICRODIALYSIS; GALANIN ANTAGONIST M15; ACETYLCHOLINE RELEASE; STRIATUM;

D O I：

10.1016/0006-8993(92)90832-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the putative galanin (GAL) antagonist M15 on the GAL-evoked release of acetylcholine (ACh) was investigated in the rat striatum using microdialysis and HPLC techniques. GAL (3 nmol/10-mu-l), applied in the lateral ventricle (i.c.v.) or perfused through the microdialysis membrane into the striatum, was found to enhance basal ACh release. The GAL-evoked release of striatal ACh was completely blocked by M15 (3 nmol/10-mu-l), administered either i.c.v. or into the striatum. This finding suggests that GAL stimulates the basal ACh release in the rat striatum by a direct action of the peptide on striatal GAL receptors.

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页码：317 / 319

页数：3

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