CIRCADIAN VARIATION OF HEPATIC UDP-GLUCURONIC ACID AND THE GLUCURONIDATION OF XENOBIOTICS IN MICE

被引:8
作者
HOWELL, SR
KLAASSEN, C
机构
[1] UNIV KANSAS,MED CTR,CTR ENVIRONM HLTH OCCUPAT MED,KANSAS CITY,KS 66103
[2] UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,KANSAS CITY,KS 66103
关键词
ACETAMINOPHEN; CIRCADIAN VARIATION; GLUCURONIDATION; SALICYLAMIDE; UDP-GLUCURONIC ACID;
D O I
10.1016/0378-4274(91)90121-L
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
A circadian cycle in hepatic UDP-glucuronic acid (UDP-GA) concentration was observed in mice that was essentially the reverse of those seen for hepatic glycogen and UDP-glucose. That is, hepatic UDP-GA levels were highest during the fasting period and lowest during the feeding period. However, there was no significant difference between the half-lives or the apparent rates of glucuronidation for either acetaminophen or salicylamide at 8 a.m. and 5 p.m. Therefore, the previously-reported circadian variation in acetaminophen toxicity is probably due to circadian variation in hepatic glutathione levels rather than in hepatic glucuronidation capacity.
引用
收藏
页码:73 / 79
页数:7
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