ANTIMICROBIAL PROPERTIES OF ALKALOIDS FROM XANTHORHIZA-SIMPLICISSIMA

被引：39

作者：

OKUNADE, AL

HUFFORD, CD

RICHARDSON, MD

PETERSON, JR

CLARK, AM

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 83卷 / 03期

关键词：

D O I：

10.1002/jps.2600830327

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The organic extract of the whole plant Xanthorhiza simplicissima was found to exhibit good activity against the AIDS-related opportunistic pathogens Candida albicans, Cryptococcus neoformans, and Mycobacterium intracellularae. Bioassay-directed fractionation of the extract led to the isolation of the known alkaloid berberine as the major active component. A second alkaloid of the isohomoprotoberberine family, puntarenine, was isolated from this plant family for the first time. Puntarenine also showed marginal activity against the dermatophytic fungus Trichophyton mentagrophytes and the yeast Saccharomyces cerevisiae.

引用

页码：404 / 406

页数：3

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