TRANSLATIONAL CONTROL OF MATERNAL GLP-1 MESSENGER-RNA ESTABLISHES AN ASYMMETRY IN THE C-ELEGANS EMBRYO

被引：200

作者：

EVANS, TC ^{[1
]}

CRITTENDEN, SL ^{[1
]}

KODOYIANNI, V ^{[1
]}

KIMBLE, J ^{[1
]}

机构：

[1] UNIV WISCONSIN, DEPT BIOCHEM, MADISON, WI 53706 USA

来源：

CELL | 1994年 / 77卷 / 02期

关键词：

D O I：

10.1016/0092-8674(94)90311-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In C. elegans, the glp-1 gene encodes a membrane receptor that is required for anterior cell fates in the early embryo. We report that GLP-1 protein is focalized to anterior blastomeres in 2- to 28-cell embryos. By contrast, glp-1 mRNA is present in all blastomeres until the 8-cell stage. Furthermore, the glp-1 3' untranslated region can restrict translation of a reporter mRNA to anterior blastomeres. Therefore, the translation of maternal glp-1 mRNA is temporally and spatially regulated in the C. elegans embryo. The regulation of maternal glp-1 mRNA has striking parallels to the regulation of maternal hunchback mRNA in the Drosophila embryo. Thus, the establishment of embryonic asymmetry in diverse organisms may involve conserved mechanisms of maternal mRNA regulation.

引用

页码：183 / 194

页数：12

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