EFFECTS OF GLUCOCORTICOIDS ON SKELETAL GROWTH IN RABBITS EVALUATED BY DUAL-PHOTON ABSORPTIOMETRY, MICROSCOPIC CONNECTIVITY AND VERTEBRAL COMPRESSIVE STRENGTH

被引：38

作者：

GRARDEL, B ^{[1
]}

SUTTER, B ^{[1
]}

FLAUTRE, B ^{[1
]}

VIGUIER, E ^{[1
]}

LAVASTE, F ^{[1
]}

HARDOUIN, P ^{[1
]}

机构：

[1] ECOLE NATL SUPER ARTS & METIERS,BIOMECAN LAB,PARIS,FRANCE

来源：

OSTEOPOROSIS INTERNATIONAL | 1994年 / 4卷 / 04期

关键词：

BONE HISTOMORPHOMETRY; CORTICOSTEROID; DUAL-PHOTON ABSORPTIOMETRY; MECHANICAL TESTING; OSTEOPOROSIS; RABBIT;

D O I：

10.1007/BF01623240

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The effects of corticosteroid on bone were examined in female growing rabbits treated with 0.7 mg/kg per day prednisolone for 5 months. The evolution of whole-body total bone mineral measured by dual-photon absorptiometry showed a significant difference between the prednisolone-treated group and the control group from the first to the fifth month. The histomorphometric profile of corticosteroid-induced osteoporosis was observed, in particular the lower bone volume and thinner and fewer trabecular plates. Mechanical tests are possible on rabbit vertebrae and showed a very significant difference in bone strength between the prednisolone-treated and control groups, and a good correlation between mechanical tests and histomorphometric or densitometric results. This bone corticosteroid model shows that vertebral compression tests are possible on rabbit lumbar vertebrae. It may contribute to a better evaluation of corticosteroid treatments.

引用

页码：204 / 210

页数：7

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