EFFECTS OF GLUCOSE AND ACETYLCHOLINE ON ISLET TISSUE NADH AND INSULIN RELEASE

被引：12

作者：

TRUS, MD

HINTZ, CS

WEINSTEIN, JB

WILLIAMS, AD

PAGLIARA, AS

MATSCHINSKY, FM

机构：

[1] Washington University School of Medicine, Department of Pharmacology St. Louis

来源：

LIFE SCIENCES | 1978年 / 22卷 / 09期

关键词：

D O I：

10.1016/0024-3205(78)90251-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The relationship between islet tissue NADH and insulin release resulting from glucose or acetylcholine was investigated with the isolated perfused rat pancreas. Switching the perfusate from 4 to 16 mM glucose or adding 1 μM acetylcholine to 4.4 mM basal glucose elicited biphasic insulin release and rapidly elevated the NADH content of islet tissue, suggesting that intermediary metabolism was stimulated. The biochemical basis for this NADH increase and its significance in islet physiology are discussed. © 1978.

引用

页码：809 / 815

页数：7

共 26 条

[1] PENTOSE CYCLE AND INSULIN RELEASE IN MOUSE PANCREATIC-ISLETS [J].