ROLE OF CARRYING MOLECULE IN CROSS-RESISTANCE AGAINST SUGAR ALCOHOL DERIVATIVES

The role of the carrying molecule in the mechanism of cross-resistance against cytostatic sugar alcohol derivatives was studied on Yoshida ascitic tumours which were rendered resistant to the hexitol derivatives Degranol, dibromodulcitol, to the tetritol-compound 1,4-dibromo-1,4-dideoxy-dl-threitol as well as to the hydroxyl-free analogue of dibromohexitols, dibromohexane. The growth inhibitory effects of various sugar alcohol derivatives were investigated on bilaterally growing solid tumours derived from the sensitive as well as from the resistant lines. The Degranol and DBD resistant tumours proved to be cross-resistant to other alkylating hexitol derivatives. The Yoshida tumours resistant to dibromothreitol were cross-resistant to dibromo-erythritol and to Myleran. An imcomplete cross-resistance was found between dibromohexane and the hexitol derivatives. No cross-resistance could be detected between the hexitol and tetritol derivatives. © 1969.