TIME COURSE OF INDUCTION OF A HEAT-SHOCK GENE (HSP70) IN THE RABBIT CEREBELLUM AFTER LSD INVIVO - INVOLVEMENT OF DRUG-INDUCED HYPERTHERMIA

被引：35

作者：

MANZERRA, P ^{[1
]}

BROWN, IR ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT ZOOL,SCARBOROUGH CAMPUS,TORONTO M1C 1A4,ONTARIO,CANADA

来源：

NEUROCHEMICAL RESEARCH | 1990年 / 15卷 / 01期

关键词：

Heat shock protein; hsp70; hyperthermia; in situ hybridization; LSD; rabbit brain;

D O I：

10.1007/BF00969184

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In situ hybridization studies were carried out to determine whether induction of hsp70 mRNA in various cellular layers of the rabbit cerebellum was due to hyperthermic effects of the psychotropic drug LSD. Results indicated that induction was not present when LSD-induced hyperthermia was blocked. The pattern of induction of hsp70 mRNA in various cell types of the cerebellum was similar when hyperthermia was induced by either drug (LSD) or nondrug means (placement of animals in a warm incubator). A time course analysis of the induction of hsp70 mRNA following LSD-induced hyperthermia revealed maximal levels of mRNA at 1 hr in all cerebellar cell layers except the Purkinje layer where highest levels were attained at 5 hr. By 10 hr hsp70 mRNA had returned to constitutive levels in all cellular layers of the cerebellum. © 1990 Plenum Publishing Corporation.

引用

页码：53 / 59

页数：7

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