STUDIES ON HYPERSENSITIVITY AND IMMUNITY CAUSED BY MYCOBACTERIUM JOHNEI PMKO/J ADJUVANT VACCINE IN SHEEP

Sheep were vaccinated with heat killed M. johnei adjuvant vaccine and an adjuvant vaccine containing peptidoglycolipid ( PMKO J) extracted from M. johnei. The M. johnei adjuvant vaccine caused a moderate to high level of hypersensitivity to tuberculins and immunity to M. johnei, while only those sheep which developed hypersensitivity to the PMKO J vaccine showed any evidence of immunity when compared with appropriate controls. © 1969.