ELECTROCARDIOGRAPHIC AND HEMODYNAMIC EFFECTS OF TOCAINIDE (W-36095) IN MAN

被引：10

作者：

SWEDBERG, K

PEHRSON, J

RYDEN, L

机构：

[1] Division of Cardiology, Department of Medicine I, Sahlgren's Hospital, Göteborg

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1978年 / 14卷 / 01期

关键词：

electrocardiography; healthy volunteers; hemodynamics; plasma concentrations; Tocainide;

D O I：

10.1007/BF00560253

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tocainide is a new antiarrhythmic drug with a chemical structure related to that of lidocaine. In the present study, healthy volunteers were investigated after infusion of tocainide 450 mg over 45 min. In nine subjects His bundle electrograms, sinus recovery time and ventricular effective refractory periods were recorded. No major changes were seen. In eight cases the hemodynamic effects at rest and during exercise were studied. No significant circulatory effects were observed. No clinically important side-effects were noted. © 1978 Springer-Verlag.

引用

页码：15 / 19

页数：5

共 8 条

[1] ANTIARRHYTHMIC AND CIRCULATORY EFFECTS OF ASTRA W36095 - NEW LIDOCAINE-LIKE AGENT [J].