PROSTAGLANDIN-E1 REVERSIBLY INDUCES MORPHOLOGICAL-CHANGES IN MACROPHAGES AND INHIBITS PHAGOCYTOSIS

被引：82

作者：

OROPEZARENDON, RL ^{[1
]}

SPETH, V ^{[1
]}

HILLER, G ^{[1
]}

WEBER, K ^{[1
]}

FISCHER, H ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM, D-3400 GOTTINGEN, FED REP GER

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 119卷 / 02期

关键词：

D O I：

10.1016/0014-4827(79)90365-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Light microscopy and scanning electron microscopy (SEM) showed that PG[prostaglandin]E1 induces a strong morphological change of cultured [mouse bone marrow] macrophages which is accompanied by a loss in membrane activity, cell locomotion and phagocytosis. All effects induced by PGE1 were fully reversible and seemed specific, since they were not induced by PGF2.alpha.. Characterization of the cytoskeleton by immunofluorescence microscopy revealed that neither microfibrils nor microtubuli were drastically changed. All PGE1 induced morphological and functional changes were fully reversible. After repeated washings, the cells were restored to their normal appearance, membrane movements and phagocytic capacity.

引用

页码：365 / 371

页数：7

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