PROGRESSIVE LOSS OF MESSENGER-RNA AND DELAYED NEURONAL DEATH FOLLOWING TRANSIENT CEREBRAL-ISCHEMIA IN GERBILS

被引：26

作者：

MARUNO, M ^{[1
]}

YANAGIHARA, T ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT NEUROL,ROCHESTER,MN 55905

来源：

NEUROSCIENCE LETTERS | 1990年 / 115卷 / 2-3期

关键词：

Cerebral ischemia; Gerbil; Hippocampus; In situ hybridization; Messenger RNA;

D O I：

10.1016/0304-3940(90)90447-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined mRNA, cytoplasmic RNA and structural damage in the hippocampus of the gerbil brain after transient ischemia by in situ hybridization, Acridine orange histochemistry and immunohisto-chemistry. Progressive decline of mRNA became visible in the CA1 region after reperfusion for 3 h and loss of cytoplasmic RNA and emergence of structural damage in 3 days. Reduction of mRNA in the CA3-CA4 region was transient. The findings suggested positive correlation between progressive loss of mRNA and delayed neuronal death. © 1990.

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页码：155 / 160

页数：6

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