EFFECT OF CALCIUM GLUCARATE ON BETA-GLUCURONIDASE ACTIVITY AND GLUCARATE CONTENT OF CERTAIN VEGETABLES AND FRUITS

被引:33
作者
DWIVEDI, C
HECK, WJ
DOWNIE, AA
LARROYA, S
WEBB, TE
机构
[1] OHIO STATE UNIV,CTR COMPREHENS CANC,COLUMBUS,OH 43210
[2] OHIO STATE UNIV,COLL MED,DEPT PHYSIOL CHEM,COLUMBUS,OH 43210
来源
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1990年 / 43卷 / 02期
关键词
D O I
10.1016/0885-4505(90)90012-P
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glucarate is normally present in tissues and body fluids and is in equilibrium with d-glucaro-1,4-lactone, a natural inhibitor of β-glucuronidase activity. Dietary calcium glucarate, a sustained-release from of glucarate, elevates the blood level of d-glucaro-1,4-lactone which suppresses blood and tissue β-glucuronidase activity. A single dose of CaG (4.5 mmole/kg body weight) inhibited β-glucuronidase activity in serum and liver, lung, and intestinal microsomes by 57, 44, 37, and 39%, respectively. A chronic administration of calcium glucarate (4% in diet) also decreased β-glucuronidase activity in intestinal and liver microsomes. Maximal inhibition of β-glucuronidase activity in serum was observed from 12 noon to 2:00 pm. In contrast, maximum inhibition of β-glucuronidase activity in intestinal and liver microsomes occurred during mornings, although a secondary depression in intestinal microsomes also occurred around 4 pm. A 4% calcium glucarate supplemented diet also inhibited β-glucuronidase activity by 70% and 54%, of the bacterial flora obtained from proximal (small intestine) and distal (colon) segments of intestine, respectively. Due to the potential effect of dietary glucarate on net glucuronidation and on other metabolic pathways, glucaric acid levels in various foods were determined. The glucaric acid content varied from a low of 1.12-1.73 mg 100 g for broccoli and potatoes to a high of 4.53 mg 100 g for oranges. © 1990.
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页码:83 / 92
页数:10
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