EFFECT OF SPECIFIC ANTIBODIES ON CHRONIC ECHOVIRUS TYPE-5 ENCEPHALITIS IN A PATIENT WITH HYPOGAMMAGLOBULINEMIA

被引:31
作者
WEINER, LS
HOWELL, JT
LANGFORD, MP
STANTON, GJ
BARON, S
GOLDBLUM, RM
LORD, RA
GOLDMAN, AS
机构
[1] UNIV TEXAS,MED BRANCH,CTR CHILD HLTH,DEPT PEDIAT,GALVESTON,TX 77550
[2] UNIV TEXAS,MED BRANCH,DEPT MICROBIOL,GALVESTON,TX 77550
[3] UNIV TEXAS,MED BRANCH,DEPT HUMAN BIOL CHEM & GENET,GALVESTON,TX 77550
基金
美国国家卫生研究院;
关键词
D O I
10.1093/infdis/140.6.858
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effects of specific antibodies in chronic echovirus type 5 (echo 5) encephalitis were investigated in a patient with x-linked hypogammaglobulinemia. Virus was detected in cerebrospinal fluid (CSF) and blood despite treatment with commercial human gammaglobulin that contained low titers of antibodies to echo 5 (0.6 × 104 units per injection). Virus disappeared from blood and CSF when plasma containing high concentrations of antibodies (total dose, 1-4 × 104 units/kg) was administered intravenously. Maximal inhibition of virus was achieved in culture and in the patient’s CSF when the titer of antibody to echo 5 in CSF was ≥ 16 units/ml. Although the patient died, hyperimmune plasma improved the neurologic status and eliminated detectable virus from the blood and CSF. © 1979 by The University of Chicago.
引用
收藏
页码:858 / 863
页数:6
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