HEAT-SHOCK RESPONSIVE ELEMENTS IN THE INDUCTION OF THE MULTIDRUG RESISTANCE GENE (MDR1)

被引：85

作者：

KIOKA, N ^{[1
]}

YAMANO, Y ^{[1
]}

KOMANO, T ^{[1
]}

UEDA, K ^{[1
]}

机构：

[1] KYOTO UNIV,DEPT AGR CHEM,BIOCHEM LAB,KYOTO 606,JAPAN

来源：

FEBS LETTERS | 1992年 / 301卷 / 01期

关键词：

MULTIDRUG RESISTANCE; MDR1; P-GLYCOPROTEIN; HEAT-SHOCK PROTEIN;

D O I：

10.1016/0014-5793(92)80205-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MDR1 gene, considered to be involved in multidrug resistance of cancer cells, is expressed in liver, kidney, small intestine and the blood-brain barrier. We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. Deletion analysis of the MDR1 promoter indicated that the transcriptional activation after exposure to arsenite depends on a 60-bp region containing two heat-shock responsive elements.

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页码：37 / 40

页数：4

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