GD-DOTA - EVALUATION OF ITS RENAL TOLERANCE IN PATIENTS WITH CHRONIC-RENAL-FAILURE

被引：36

作者：

BELLIN, MF

DERAY, G

ASSOGBA, U

AUBERTON, E

GHANY, F

DIONVOIRIN, E

JACOBS, C

GRELLET, J

机构：

[1] Department of Radiology, Hôpital la Pitié, 75651 Paris Cedex 13

[2] Department of Nephrology, Hôpital La Pitié, 75651 Paris Cedex 13

来源：

MAGNETIC RESONANCE IMAGING | 1992年 / 10卷 / 01期

关键词：

KIDNEY; CONTRAST MEDIUM; MAGNETIC RESONANCE IMAGING;

D O I：

10.1016/0730-725X(92)90380-I

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Gd-DOTA is an intravenous contrast medium used in MRI. The clinical and biological tolerance of Gd-DOTA was studied in patients with chronic renal failure (e.g., those having a glomerular filtration rate of less than 60 mL/min). Twenty patients were randomized into two groups. In the control group, spin-echo (SE) T1- and T2- weighted images of the kidneys were obtained without injection of Gd-DOTA. In the DOTA-group, patients received 0.1 mmol/kg of Gd-DOTA. SE T1-weighted images were obtained before and after injections; a T2- weighted sequence was performed before injection. Clinical data, serum creatinine, and laboratory parameters were estimated before, and 24 and 48 hr after MRI. No adverse reaction was reported after injection of Gd-DOTA. Mean serum creatinine and glomerular filtration rate remained unchanged in both groups. For five patients in the control group and three patients in the DOTA-group the serum creatinine levels increased more than 10% and less than 25%. No evidence of nephrotoxicity was observed with Gd-DOTA in patients with chronic renal failure.

引用

页码：115 / 118

页数：4

共 8 条

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