NEW APPROACH TO THE ESTIMATION OF THE EXTENT OF MYOCARDIAL FIBROSIS IN PATIENTS WITH DILATED CARDIOMYOPATHY - USE OF SIGNAL-AVERAGED ELECTROCARDIOGRAPHY

被引：41

作者：

YAMADA, T ^{[1
]}

FUKUNAMI, M ^{[1
]}

OHMORI, M ^{[1
]}

IWAKURA, K ^{[1
]}

KUMAGAI, K ^{[1
]}

KONDOH, N ^{[1
]}

TSUJIMURA, E ^{[1
]}

ABE, Y ^{[1
]}

NAGAREDA, T ^{[1
]}

KOTOH, K ^{[1
]}

HOKI, N ^{[1
]}

机构：

[1] OSAKA PREFECTURAL HOSP,DIV PATHOL,OSAKA 558,JAPAN

来源：

AMERICAN HEART JOURNAL | 1993年 / 126卷 / 03期

关键词：

D O I：

10.1016/0002-8703(93)90413-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To determine whether the extent of myocardial fibrosis in dilated cardiomyopathy could be estimated noninvasively, signal-averaged electrocardiograms were recorded in 32 patients with dilated cardiomyopathy, followed by left ventricular endomyocardial biopsy. The root mean square voltage for the last 40 msec (V40), the duration of the filtered QRS complex (fQRSd) and the duration of low amplitude signals < 40 muV (LAS) were obtained by signal-averaged electrocardiography. The extent of fibrosis in all biopsy samples was measured by the point-counting method. The extent of myocardial fibrosis closely correlated with fQRSd (r = 0.623, p < 0.001), LAS (r = 0.570, p < 0.001), and V40 (r = -0.355, p < 0.05). When fibrosis was classified into intercellular and interfascicular types, the extent of intercellular fibrosis more closely correlated with fQRSd (r = 0.695, p < 0.0001), LAS (r = 0.640, p < 0.0001), and V40 (r = -0.533, p < 0.005). These results suggest that signal-averaged electrocardiograms might be useful for estimation of the extent of myocardial fibrosis, especially intercellular fibrosis in patients with dilated cardiomyopathy.

引用

页码：626 / 631

页数：6

共 35 条

[1] A RANDOMIZED TRIAL OF LOW-DOSE BETA-BLOCKADE THERAPY FOR IDIOPATHIC DILATED CARDIOMYOPATHY [J].