ASCORBATE-DEPENDENT ELEVATION OF MESSENGER-RNA LEVELS FOR CYTOCHROME-P450S INDUCED BY POLYCHLORINATED-BIPHENYLS

被引：10

作者：

SUZUKI, H ^{[1
]}

TORII, Y ^{[1
]}

HITOMI, K ^{[1
]}

TSUKAGOSHI, N ^{[1
]}

机构：

[1] NAGOYA UNIV,FAC AGR,DEPT APPL BIOL SCI,CHIKUSA KU,NAGOYA 46401,JAPAN

来源：

BIOCHEMICAL PHARMACOLOGY | 1993年 / 46卷 / 01期

关键词：

D O I：

10.1016/0006-2952(93)90365-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Trichlorobiphenyl induced only CYP1A2 mRNA, while pentachlorobiphenyl induced both CYP1A2 and CYP2B1 mRNAs in rat liver. The mRNA levels for these P450s were elevated when ascorbic acid-deficient ODS rats (mutant rats with a hereditary osteogenic disorder) were fed a diet supplemented with ascorbic acid. The amount of CYP2B1 mRNA increased rapidly and reached a maximum level of approximately double within 24 hr of injection of pentachlorobiphenyl. Thereafter, the amount of its mRNA decreased to a steady level. This pattern was roughly paralleled by changes in the amount of CYP1A2 mRNA.

引用

页码：186 / 189

页数：4

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