CHANGES IN ENERGY METABOLITES, CGMP AND INTRACELLULAR PH DURING CORTICAL SPREADING DEPRESSION

被引：40

作者：

GAULT, LM

LIN, CW

LAMANNA, JC

LUST, WD

机构：

[1] CASE WESTERN RESERVE UNIV,SCH MED,EXPTL NEUROSURG LAB,BRB,10900 EUCLID AVE,CLEVELAND,OH 44106

[2] UNIV HOSP CLEVELAND,EXPTL NEUROSURG LAB,CLEVELAND,OH 44106

[3] UNIV HOSP CLEVELAND,DEPT NEUROL,CLEVELAND,OH 44106

[4] CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROL,CLEVELAND,OH 44106

来源：

BRAIN RESEARCH | 1994年 / 641卷 / 01期

关键词：

ADENOSINE TRIPHOSPHATE; CYCLIC GUANOSINE 3'5'-MONOPHOSPHATE; ENERGY METABOLITE; INTRACELLULAR PH; LACTATE; PHOSPHOCREATINE; RAT BRAIN; SPREADING DEPRESSION;

D O I：

10.1016/0006-8993(94)91835-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The spatial and temporal distribution of cerebral metabolites and pH(i) were examined in the cortex during spreading depression. Acidification and marked depression in the energy status of the tissue was evident at the wavefront of spreading depression. In its aftermath, the residual activation of glycolysis and accumulation of cGMP persisted for minutes after a relatively rapid restoration of high-energy phosphates and pH(i).

引用

页码：176 / 180

页数：5

共 20 条

[1] RESISTANCE OF BRAIN PHOSPHOFRUCTO-1-KINASE TO PH-DEPENDENT INHIBITION [J].